Network showing functional relationships between the small metabolic compounds in TB patients, healthy uninfected and latently infected individuals.

Nodes correspond to metabolites; edges correspond to statistically significant correlation between residual small metabolite profiles corrected for study classes. Colors correspond to differences between the TST+ and classes (see Figure S3 for additional comparisons). Color intensity indicates significance of difference with darker colors corresponding to more significant differences. Metabolites with adjusted p value >0.05 are not colored. Line thickness corresponds to the absolute Spearman correlation coefficients corrected for groups (see Methods). See also Figure S3.