Next Generation Sequencing Facilitates Quantitative Analysis of Bone Marrow Macrophages and Splenic Macrophages Transcriptomes in Mouse MLL-AF9 AML Leukemia. Mus musculus

The goals of this study aim to reveal functional and phenotypic diversity of leukemia-associated macrophages in response to the microenvironmental cues in mouse MLL-AF9 AML leukemia Overall design: Compare transcriptomes of macrophages in mouse MLL-AF9 AML leukemia which are suggested as leukemia-associated macrophages (LAMs) with homeostasis and LAMs from mouse acute Myeloid leukemia.