Combination Surgical Prophylaxis with Vancomycin versus Standard Prophylaxis for the Prevention of Surgical Site Infections following Elective and Expedited Surgery

Single dose intravenous vancomycin (1.5g) administered immediately prior to commencement of surgery. The vancomycin will be administered by the anaesthetist. In addition to vancomycin, all participants will receive standard surgical antimicrobial prophylaxis with intravenous cefazolin (2g). The dose, timing and frequency of cefazolin is in keeping with national guidelines (Therapeutic Guidelines: Antibiotics) as part of standard care.将在手术开始前即刻给予单次静脉输注万古霉素（vancomycin）1.5g，该给药操作由麻醉医师执行。除万古霉素外，所有受试者均将接受标准外科抗菌预防治疗，予以静脉输注头孢唑林（cefazolin）2g。头孢唑林的给药剂量、时机与频次均符合国家指南《治疗指南：抗生素》（Therapeutic Guidelines: Antibiotics）的相关要求，作为标准诊疗的组成部分。