cryo-EM structure of Vitamin K-dependent gamma-carboxylase complexed with anisindione

cryo-EM structure of Vitamin K-dependent gamma-carboxylase complexed with anisindione Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Yao, D, Wu, K, Lan, P. Deposit date: 2024-12-16 Release date: 2025-10-22 Last modified: 2026-05-06 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase. Nat Commun, 16, 2025与茴茚二酮（anisindione）结合的维生素K依赖型γ-羧化酶（Vitamin K-dependent gamma-carboxylase）的冷冻电镜（cryo-EM）结构。样本描述：1,2-二油酰基-sn-甘油-3-磷酸乙醇胺（1,2-dioleoyl-sn-glycero-3-phosphoethanolamine）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose）…… 作者：Yao, D、Wu, K、Lan, P。存档日期：2024-12-16。发布日期：2025-10-22。最后更新日期：2026-05-06。实验方法：电子显微镜法（分辨率2.82埃（Å））。引用文献：《人类维生素K依赖型羧化酶介导碳酸氢盐羧化的结构洞察》，《自然·通讯》（Nat Commun），2025年，第16卷。