Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). Reported haplotype lengths range from 67 to 269 kb and contain 4 to 18 genes. The region has certain p

NIAID Data Ecosystem40

Flexible chromatin loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire

免疫基因组学

染色质结构

The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates VH-DJH recombination by juxtaposing distal VH genes next to the DJH- rearranged gene segm

NIAID Data Ecosystem40

Identification of differentially expressed genes between control and PIK3CD GOF human activated transitional B cells. Identification of differentially expressed genes between control and PIK3CD GOF human activated transitional B cells

免疫基因组学

细胞功能研究

IL-21 induces B cell activation, and differentiation into antibody-secreting plasmblasts in vitro. This process is compromised in transitional B cells to gain of function mutations in PIK3CD We used m

NIAID Data Ecosystem50

Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways

免疫基因组学

中性粒细胞炎症反应

As part of the Immunological Genome Project (ImmGen), gene expression was determined in unstimulated (circulating) mouse neutrophils and three populations of neutrophils activated in vivo, with compar

NIAID Data Ecosystem40

Overview of eight selected immune system loci in GRCh38.

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