A new isocoumarin derivative from endophytic fungus <i>Pezicula neosporulosa</i> VDB39 from <i>Vaccinium dunalianum</i>

Four isocoumarin derivatives (1–4) and five phenols (5–9) were obtained from the endophytic fungus Pezicula neosporulosa VDB39, which was isolated from the branches of Vaccinium dunalianum Wight (Ericaceae). Compound 1 is a new derivative of isocoumarin. The structures were elucidated by spectroscopic methods. Single X-ray crystallography confirmed the absolute configuration of compound 1. Additionally, the antiphytopathogenic fungi activity of isocoumarin derivatives (1–4) was evaluated.本研究从分离自杜鹃花科（Ericaceae）乌饭树（Vaccinium dunalianum Wight）枝条的内生真菌（endophytic fungus）新孢盘菌Pezicula neosporulosa VDB39中，分离得到4个异香豆素（isocoumarin）类衍生物（1~4）与5个酚类化合物（5~9）。其中，化合物1为新型异香豆素衍生物。所有化合物的结构均通过波谱学方法解析确定；单晶X射线衍射实验确证了化合物1的绝对构型。此外，本研究还评价了异香豆素类衍生物1~4的抗植物病原真菌活性。