Discovery of a novel sub-lineage of multi-drug resistant Shigella flexneri in Southern California

A 60-year-old man with history of men who have sex with men presented after experiencing new episodes of diarrhea, about a months after the initial empirical treated with a 3-day course of azithromycin failed. Shigella was isolated from the stool, and was sequenced to guide treatment.一名有男男性行为史（men who have sex with men）的60岁男性，在初始经验性阿奇霉素（azithromycin）3天疗程治疗失败约1个月后，因出现新发腹泻症状就诊。后续从其粪便标本中分离出志贺菌（Shigella），并对该菌株进行测序以指导临床治疗。