Most common genetic variants associated with disease are located in non-coding regions of the genome. One mechanism by which they function is through altering transcription factor (TF) binding. In thi

NIAID Data Ecosystem30

CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions [ChIP-seq]

基因调控机制

疾病基因功能分析

ChIP-seq was performed to identify dCas9-KRAB binding sites in the presence of sgRNA (sgTGFB1_B9D2) targeting a region with rs1800469 between TGFB1 and B9D2 in H441 lung papillary adenocarcinoma cells

NIAID Data Ecosystem20

Wobble base paired RNA double helix

RNA结构生物学

摆动碱基配对

Wobble base paired RNA double helix Descriptor: RNA (5'-R(*UP*GP*UP*UP*CP*UP*CP*UP*AP*CP*GP*AP*AP*GP*AP*AP*CP*A)-3') Authors: Garg, A, Heinemann, U. Deposit date: 2017-05-10 Release date: 2017-11-29 L

Protein Data Bank Japan2024-01-17 更新30

The Human Accelerated Region HACNS1 modifies developmental gene expression in humanized mice

发育生物学

基因调控机制

Understanding how uniquely human genetic changes altered developmental processes is essential to understanding human evolution. We investigated the role of the Human Accelerated Region HACNS1 in human

NIAID Data Ecosystem30

Crystal structure of the SAM-SAH riboswitch with adenosine.

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