X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with an inhibitor 617 Descriptor: (2~{S})-2-[[(2~{S})-6-[[(2~{S})-3-naphthalen-2-yl-2-[[4-[[2-[(11~{Z})-4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-11-en-1-yl]ethanoylamino]methyl]cyclohexyl]carbonylamino]propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Motlova, L, Barinka, C, Benesova, M. Deposit date: 2022-11-15 Release date: 2023-11-29 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structure-Activity Relationships and Biological Insights into PSMA-617 and Its Derivatives with Modified Lipophilic Linker Regions. Acs Omega, 10, 2025人类谷氨酸羧肽酶II（GCPII）与抑制剂617结合的X射线晶体结构 描述符：(2S)-2-[[(2S)-6-[[(2S)-3-萘-2-基-2-[[4-[[2-[(11Z)-4,7,10-三(2-羟基-2-氧代乙基)-1,4,7,10-四氮杂环十二-11-烯-1-基]乙酰氨基]甲基]环己基]羰基氨基]丙酰基]氨基]-1-羟基-1-氧代己-2-基]氨基甲酰氨基]戊二酸，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，…… 作者：Motlova L、Barinka C、Benesova M 提交日期：2022-11-15 发布日期：2023-11-29 最后修改日期：2026-03-04 实验方法：X射线衍射（分辨率1.58埃） 引用文献：《PSMA-617及其修饰亲脂连接区衍生物的构效关系与生物学研究》，Acs Omega，2025年，第10卷