Mixed model analysis of laboratory parameters: Model 1 with adjustment for time cluster, age and sex; Model 2 with adjustment for time cluster and age; Model 3 with adjustment for time cluster, age and interaction of laboratory value quartile with time cluster; Interaction term model M3 indicates strengths and significance of interaction between laboratory values and time cluster.

Mixed model analysis of laboratory parameters: Model 1 with adjustment for time cluster, age and sex; Model 2 with adjustment for time cluster and age; Model 3 with adjustment for time cluster, age and interaction of laboratory value quartile with time cluster; Interaction term model M3 indicates strengths and significance of interaction between laboratory values and time cluster.实验室检测参数的混合模型分析：模型1校正了时间集群（time cluster）、年龄与性别；模型2校正了时间集群（time cluster）与年龄；模型3校正了时间集群（time cluster）、年龄以及实验室检测值四分位数与时间集群的交互项；交互项模型M3用于表征实验室检测值与时间集群之间交互作用的强度与显著性。